Arteriovenous Hemofiltration: A Kidney Replacement Therapy by Peter Kramer

By Peter Kramer

Discovery and Relative value of constant Arteriovenous HemofIltration Lee W. Henderson non-stop arteriovenous hemofiltration (CAVH) has noticeable a brisk upswing in reputation in Europe in view that its advent via Dr. Kramer and co-workers from Gottingen, West Germany in 1977 [1]. within the usa, the procedure re ceived approval as a scientific software from the nutrients and Drug management in April 1982. This approval flowed, in no small degree, from the vast expe rience said from Europe and specifically West Germany [e. g., 2, 3]. experiences of its medical application now have began to seem within the usa [4]. elimination of extra overall physique water utilizing artificial membranes in an extracor poreal circuit dates again to the paintings of Alwall and the factitious kidney that he designed which authorized usage of a hydrostatic strain gradient to moti vate water circulate around the membrane [5]. Kolffs unique rotating drum with its unencased membrane required an osmotic motive force [6]. Hemofiltration, using the filtration approach to take away uremic solutes with the substitute kidney, in analogy with the glomerulus, used to be stated in 1967 [7]. This was once made attainable through the provision of man-made membranes with a long way greater hydraulic permeability (approximately 10 occasions larger) than conventionally used cellulosic hemodialysis membrane. particular functions of those "high flux" membranes to the elimination basically of extra overall physique water almost immediately thereafter [8].

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